Investigation on the Effect of <i>Parkia biglobosa</i> Seed Extract on the Prostate of Male Wistar Rats

Kebe Edet Obeten; Gabriel Udo-Affah; Ettah Ettah Nkanu; Wonah Eriaowo Justice

doi:doi:10.11648/j.ijcda.20210702.11

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Investigation on the Effect of Parkia biglobosa Seed Extract on the Prostate of Male Wistar Rats

Kebe Edet Obeten, Gabriel Udo-Affah, Ettah Ettah Nkanu, Wonah Eriaowo Justice

Published in International Journal of Clinical and Developmental Anatomy (Volume 7, Issue 2)

Received: 2 May 2021 Accepted: 24 June 2021 Published: 13 July 2021

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Abstract

The research was directed at assessing the prostatic effect of the extract of Parkia biglobosa on the male Wistar rats. Twenty one (21) experimental rats weighing about 90-120 g and divided into three groups consisting of seven animals were used. The control group was fed with normal rat feed and water, while the experimental groups the low and high groups received (300 mg/kgBw) and (500 mg/kgBw) of the extract daily by oral gavage method for thirty one (31) days. All animals were sacrificed a day after the end of the extract administration by cervical dislocation. The prostate was removed, weighed and fix in 10% buffer formalin. Result showed that following administration of extract of Parkia biglobosa, a significant increase was observed in the test group. Histological observation show that administration of Parkia biglobosa at high dose and long duration could result to cystic changes in the epithelium. Study reveals that these focal areas of cystic changes are prognosis of benign prostatic hyperplasia. Other histological observation shows that administration of aqueous extract of Parkia biglobosa at high dose reveal congestion of blood vessels and functional hyperplasia characterized by increased in-folding of the glandular epithelium resulting in the decrease in glandular diameter. Histochemical observation reveals a weak PAS-positive epithelial nuclei and a weak to negative PAS- positive cytoplasm, studies reveal that this could cause atrophic tubules and reactive hyperplasia.

Published in	International Journal of Clinical and Developmental Anatomy (Volume 7, Issue 2)
DOI	10.11648/j.ijcda.20210702.11
Page(s)	23-28
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Parkia biglobosa, Prostate, Functional Hyperplasia, Histochemical, PAS Stains

References

[1]	Uaboi-Egbenni, P. O., Okolie, P. N., Sobande, A. O., Alao, O., Teniola, O. and Bessong, P. O., (2009). “Identification of subdominant lactic acid bacteria in dawadawa (a soup condiment) and their evolution during laboratory-scale fermentation of Parkia biglobosa (African locust beans)”, Afr. J. Biotech., 8 (25), pp. 7241–7248.
[2]	Cook, J. A., Vanderjagt, D. J., Pastuszyn, A., Moukalia, G., Glew, R. S., Millson, M., Glew, R. H. (2000). Nutrient and Chemical composition of 13 wild plant foods of Nigeria. Journal of Food Composition Analysis, 13, 3-92.
[3]	Olorunmaiye, K. S., Fatoba, P. O. Adeyemi, O. C. and Olorunmaiye, P. M. (2011). Fruit and seed characteristics among selected Parkia biglobosa (JACQ) G. Don. Population. Agric. Biol. Journal. North Am. 2: 244-249.
[4]	Modupe Elizabeth Ojewumi, Benjamen Eluagwule, Ayodeji A. Ayoola, Ajibola Temitope Ogunbiyi, John Adeoye, Moses Eterigho Emetere and Olufunmilayo O. Joseph, (2017). “Termiticidal effects of African locust bean seed oil extract,” Inter. J. Curr. Res., 9 (07), pp. 53929-53934.
[5]	Ademola, I. T., Baiyewu, R. A., Adekunle, E. A., Omidiran, M. B. &Adebawo, F. G. (2011). An Assessment into Physical and Proximate Analysis of Processed Locust Bean (Parkia biglobosa) preserved with common salt. Pakistan Journal of Nutrition, 10 (5): 405-408.
[6]	Azokpota, P., Hounhouigan, D. J., Nago, M. C. (2005). Microbiological and chemical Changes durimg the fermentation of African locust bean (Parkia biglobosa) to Produceafintin, iru and sonru, three traditional condiments produced in Benin. International Journal of Food Microbiology, 107, 304–309.
[7]	Odunfa SA. A note on the microorganisms associated with the fermentation of African locust bean (Parkiafilicoidea) during iru production, Journal Plant Foods. 1981a; 3: 245-250.
[8]	Azokpota, Paulin (2006). Esterase and protease activities of Bacillus spp. From Afitin, iru and sonru; three African locust bean (Parkia biglobosa) condiments from Benin. African Journal of Biotechnology, 5 (3): 265-272.
[9]	Thiombiano, D. N. E., N. Lamien, A. M. Castro-Euler, B. Vinceti, D. Agundez, and I. J. Boussim. (2013. Local communities demand for food tree species and the potentialities of their landscapes in two ecological zones of Burkina Faso. Open Journal of Forestry 3 (3): 79–87.
[10]	Vinceti, B., C. Termote, N. Thiombiano, D. Agundez, and N. Lamien. (2018). Food tree species consumed during periods of food shortage in Burkina Faso and their threats. Forest Systems 27 (2): e006.
[11]	Campbell-Platt, G., 1980, “African locust bean (Parkia species) and its West African fermented food products, Dawadawa.”, Eco. Food Nutr. J., 9, pp. 123-132.
[12]	Pehou, C., H. Djoudi, B. Vinceti, M., Elias. (2020). Intersecting and dynamic gender rights to néré, a food tree species in Burkina Faso. Journal of Rural Studies 76: 230–9.
[13]	Gernah D. I., Atolagbo M. O., Echego cc (2007) nutritional composition of the African locus bean (Parkia biglobosa) fruit pulp. Niger. Food. J 25 (1): 190-196.
[14]	Ntui, V. O., Uyoh, E. A., Urua, I. S., Ogbu, U., &Okpako, E. C. (2012). Regeneration of Parkia biglobosa. An important tree species of Africa. Journal of Microbiology and Biotechnology Research, 2 (1): 169-177.
[15]	Dada, A. A. & Ajilore, V O. (2009). Use of ethanol extracts of Garcinia kola as fertility enhancer in female catfish Clariasgariepinusbroodstock. International Journal of Fishery and Aquaculture. 1 (1): 005-010.
[16]	Adedeji, O. S., Farimi, G. O., Ameen, S. A & Olayemi, J. B. (2006b). Effects of bitter kola (Garcinial kola) as growth promoter in Broiler Chicks from day old to four weeks old. Journal of Animal and Veterinary Advances. 5 (3): 191-193.
[17]	Obeten, K. E., Victor A Fischer, Gabriel Udo-Affah, Etah E Nkanu (2019) “Prostatic Study of Extract of Sida Acuta on Waster rats”ACTA Scientific Pharmaceutical Sciences. 3 (8): 29-33.
[18]	Konaté, K., Souza, A. Lamidi, M. Siawaya, J. F. Djoba, F. H. Ella, M., J. Millogo-Rasolodimby & Nacoulma, O. G. (2011). Biological and toxicological effects of aqueous acetone extract of Cienfuegosiadigitata Cav. (Malvaceae) in mice and rats. Journal of Pharmacology and Toxicology. 6 (2): 149-157.
[19]	Raza, M. O. Al-Shabanah, A. O., El-Hadiyah, T. M. & Al-Mayed, A. A. (2002). Effect of prolong vigabatrin on hematological and biochemical parameters in plasma, liver and kidney of Swiss albino mice. Scientific pharmaceutics. 70: 135-145.
[20]	Teo, S., Stirling D., Thomas S., Hoberman, A., Kiorpes A. & Vikram K. (2002). A 90-day oral gavage toxicity study of D-methylphenidate and D, L methyl-phenidate in sprague-dawley rats. Toxicology. 179: 188-196.
[21]	Ying Piao, Yunen Liu, and Xiaodong Xie (2013). “Change Trends of Organ Weight Background Data in Sprague Dawley Rats at Different Ages”. Journal of Toxicology Pathology. 26 (1): 29–34.
[22]	Okamura, T., Suzuki, S., Ogawa, T., Kobayashi, J., Kusuoka, O., Hatayama, K., Mochizuiki, M, hoshima, T., Okazaki, S., and Tamura, K. (2011). Background data for general toxicology parameters in RccHanTM: WIST rats at 8, 10, 19 and 32 weeks of age. Journal of toxicology and pathology.
[23]	Cotran R. S., Kumar V., Robbins S. L. (1989 Robbins’ pathologic basis of disease. 4th ed. Philadelphia: Saunders, 1989; 1119-1121.

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APA Style

Kebe Edet Obeten, Gabriel Udo-Affah, Ettah Ettah Nkanu, Wonah Eriaowo Justice. (2021). Investigation on the Effect of Parkia biglobosa Seed Extract on the Prostate of Male Wistar Rats. International Journal of Clinical and Developmental Anatomy, 7(2), 23-28. https://doi.org/10.11648/j.ijcda.20210702.11

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ACS Style

Kebe Edet Obeten; Gabriel Udo-Affah; Ettah Ettah Nkanu; Wonah Eriaowo Justice. Investigation on the Effect of Parkia biglobosa Seed Extract on the Prostate of Male Wistar Rats. Int. J. Clin. Dev. Anat. 2021, 7(2), 23-28. doi: 10.11648/j.ijcda.20210702.11

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AMA Style

Kebe Edet Obeten, Gabriel Udo-Affah, Ettah Ettah Nkanu, Wonah Eriaowo Justice. Investigation on the Effect of Parkia biglobosa Seed Extract on the Prostate of Male Wistar Rats. Int J Clin Dev Anat. 2021;7(2):23-28. doi: 10.11648/j.ijcda.20210702.11

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@article{10.11648/j.ijcda.20210702.11,
  author = {Kebe Edet Obeten and Gabriel Udo-Affah and Ettah Ettah Nkanu and Wonah Eriaowo Justice},
  title = {Investigation on the Effect of Parkia biglobosa Seed Extract on the Prostate of Male Wistar Rats},
  journal = {International Journal of Clinical and Developmental Anatomy},
  volume = {7},
  number = {2},
  pages = {23-28},
  doi = {10.11648/j.ijcda.20210702.11},
  url = {https://doi.org/10.11648/j.ijcda.20210702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcda.20210702.11},
  abstract = {The research was directed at assessing the prostatic effect of the extract of Parkia biglobosa on the male Wistar rats. Twenty one (21) experimental rats weighing about 90-120 g and divided into three groups consisting of seven animals were used. The control group was fed with normal rat feed and water, while the experimental groups the low and high groups received (300 mg/kgBw) and (500 mg/kgBw) of the extract daily by oral gavage method for thirty one (31) days. All animals were sacrificed a day after the end of the extract administration by cervical dislocation. The prostate was removed, weighed and fix in 10% buffer formalin. Result showed that following administration of extract of Parkia biglobosa, a significant increase was observed in the test group. Histological observation show that administration of Parkia biglobosa at high dose and long duration could result to cystic changes in the epithelium. Study reveals that these focal areas of cystic changes are prognosis of benign prostatic hyperplasia. Other histological observation shows that administration of aqueous extract of Parkia biglobosa at high dose reveal congestion of blood vessels and functional hyperplasia characterized by increased in-folding of the glandular epithelium resulting in the decrease in glandular diameter. Histochemical observation reveals a weak PAS-positive epithelial nuclei and a weak to negative PAS- positive cytoplasm, studies reveal that this could cause atrophic tubules and reactive hyperplasia.},
 year = {2021}
}

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TY  - JOUR
T1  - Investigation on the Effect of Parkia biglobosa Seed Extract on the Prostate of Male Wistar Rats
AU  - Kebe Edet Obeten
AU  - Gabriel Udo-Affah
AU  - Ettah Ettah Nkanu
AU  - Wonah Eriaowo Justice
Y1  - 2021/07/13
PY  - 2021
N1  - https://doi.org/10.11648/j.ijcda.20210702.11
DO  - 10.11648/j.ijcda.20210702.11
T2  - International Journal of Clinical and Developmental Anatomy
JF  - International Journal of Clinical and Developmental Anatomy
JO  - International Journal of Clinical and Developmental Anatomy
SP  - 23
EP  - 28
PB  - Science Publishing Group
SN  - 2469-8008
UR  - https://doi.org/10.11648/j.ijcda.20210702.11
AB  - The research was directed at assessing the prostatic effect of the extract of Parkia biglobosa on the male Wistar rats. Twenty one (21) experimental rats weighing about 90-120 g and divided into three groups consisting of seven animals were used. The control group was fed with normal rat feed and water, while the experimental groups the low and high groups received (300 mg/kgBw) and (500 mg/kgBw) of the extract daily by oral gavage method for thirty one (31) days. All animals were sacrificed a day after the end of the extract administration by cervical dislocation. The prostate was removed, weighed and fix in 10% buffer formalin. Result showed that following administration of extract of Parkia biglobosa, a significant increase was observed in the test group. Histological observation show that administration of Parkia biglobosa at high dose and long duration could result to cystic changes in the epithelium. Study reveals that these focal areas of cystic changes are prognosis of benign prostatic hyperplasia. Other histological observation shows that administration of aqueous extract of Parkia biglobosa at high dose reveal congestion of blood vessels and functional hyperplasia characterized by increased in-folding of the glandular epithelium resulting in the decrease in glandular diameter. Histochemical observation reveals a weak PAS-positive epithelial nuclei and a weak to negative PAS- positive cytoplasm, studies reveal that this could cause atrophic tubules and reactive hyperplasia.
VL  - 7
IS  - 2
ER  -

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Author Information

Kebe Edet Obeten

Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University Western Campus, Kampala, Uganda
Gabriel Udo-Affah

Department of Anatomy, University of Calabar, Calabar, Nigeria
Ettah Ettah Nkanu

Department of Physiology, Cross River University of Technology, Okuku, Nigeria
Wonah Eriaowo Justice

Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University Western Campus, Kampala, Uganda

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APA Style

Kebe Edet Obeten, Gabriel Udo-Affah, Ettah Ettah Nkanu, Wonah Eriaowo Justice. (2021). Investigation on the Effect of Parkia biglobosa Seed Extract on the Prostate of Male Wistar Rats. International Journal of Clinical and Developmental Anatomy, 7(2), 23-28. https://doi.org/10.11648/j.ijcda.20210702.11

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ACS Style

Kebe Edet Obeten; Gabriel Udo-Affah; Ettah Ettah Nkanu; Wonah Eriaowo Justice. Investigation on the Effect of Parkia biglobosa Seed Extract on the Prostate of Male Wistar Rats. Int. J. Clin. Dev. Anat. 2021, 7(2), 23-28. doi: 10.11648/j.ijcda.20210702.11

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AMA Style

Kebe Edet Obeten, Gabriel Udo-Affah, Ettah Ettah Nkanu, Wonah Eriaowo Justice. Investigation on the Effect of Parkia biglobosa Seed Extract on the Prostate of Male Wistar Rats. Int J Clin Dev Anat. 2021;7(2):23-28. doi: 10.11648/j.ijcda.20210702.11

Copy | Download

@article{10.11648/j.ijcda.20210702.11,
  author = {Kebe Edet Obeten and Gabriel Udo-Affah and Ettah Ettah Nkanu and Wonah Eriaowo Justice},
  title = {Investigation on the Effect of Parkia biglobosa Seed Extract on the Prostate of Male Wistar Rats},
  journal = {International Journal of Clinical and Developmental Anatomy},
  volume = {7},
  number = {2},
  pages = {23-28},
  doi = {10.11648/j.ijcda.20210702.11},
  url = {https://doi.org/10.11648/j.ijcda.20210702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcda.20210702.11},
  abstract = {The research was directed at assessing the prostatic effect of the extract of Parkia biglobosa on the male Wistar rats. Twenty one (21) experimental rats weighing about 90-120 g and divided into three groups consisting of seven animals were used. The control group was fed with normal rat feed and water, while the experimental groups the low and high groups received (300 mg/kgBw) and (500 mg/kgBw) of the extract daily by oral gavage method for thirty one (31) days. All animals were sacrificed a day after the end of the extract administration by cervical dislocation. The prostate was removed, weighed and fix in 10% buffer formalin. Result showed that following administration of extract of Parkia biglobosa, a significant increase was observed in the test group. Histological observation show that administration of Parkia biglobosa at high dose and long duration could result to cystic changes in the epithelium. Study reveals that these focal areas of cystic changes are prognosis of benign prostatic hyperplasia. Other histological observation shows that administration of aqueous extract of Parkia biglobosa at high dose reveal congestion of blood vessels and functional hyperplasia characterized by increased in-folding of the glandular epithelium resulting in the decrease in glandular diameter. Histochemical observation reveals a weak PAS-positive epithelial nuclei and a weak to negative PAS- positive cytoplasm, studies reveal that this could cause atrophic tubules and reactive hyperplasia.},
 year = {2021}
}

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TY  - JOUR
T1  - Investigation on the Effect of Parkia biglobosa Seed Extract on the Prostate of Male Wistar Rats
AU  - Kebe Edet Obeten
AU  - Gabriel Udo-Affah
AU  - Ettah Ettah Nkanu
AU  - Wonah Eriaowo Justice
Y1  - 2021/07/13
PY  - 2021
N1  - https://doi.org/10.11648/j.ijcda.20210702.11
DO  - 10.11648/j.ijcda.20210702.11
T2  - International Journal of Clinical and Developmental Anatomy
JF  - International Journal of Clinical and Developmental Anatomy
JO  - International Journal of Clinical and Developmental Anatomy
SP  - 23
EP  - 28
PB  - Science Publishing Group
SN  - 2469-8008
UR  - https://doi.org/10.11648/j.ijcda.20210702.11
AB  - The research was directed at assessing the prostatic effect of the extract of Parkia biglobosa on the male Wistar rats. Twenty one (21) experimental rats weighing about 90-120 g and divided into three groups consisting of seven animals were used. The control group was fed with normal rat feed and water, while the experimental groups the low and high groups received (300 mg/kgBw) and (500 mg/kgBw) of the extract daily by oral gavage method for thirty one (31) days. All animals were sacrificed a day after the end of the extract administration by cervical dislocation. The prostate was removed, weighed and fix in 10% buffer formalin. Result showed that following administration of extract of Parkia biglobosa, a significant increase was observed in the test group. Histological observation show that administration of Parkia biglobosa at high dose and long duration could result to cystic changes in the epithelium. Study reveals that these focal areas of cystic changes are prognosis of benign prostatic hyperplasia. Other histological observation shows that administration of aqueous extract of Parkia biglobosa at high dose reveal congestion of blood vessels and functional hyperplasia characterized by increased in-folding of the glandular epithelium resulting in the decrease in glandular diameter. Histochemical observation reveals a weak PAS-positive epithelial nuclei and a weak to negative PAS- positive cytoplasm, studies reveal that this could cause atrophic tubules and reactive hyperplasia.
VL  - 7
IS  - 2
ER  -

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